| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | @ Mississippi St | 48 | 10.52 | 34 - 35 |
| 2021-09-11 | SE Louisiana | 147 | 73.06 | 45 - 42 |
| 2021-09-18 | SMU | 62 | 22.94 | 37 - 39 |
| 2021-09-25 | North Texas | 155 | 75.82 | 24 - 17 |
| 2021-10-02 | @ NC State | 37 | 10.73 | 27 - 34 |
| 2021-10-16 | @ UTEP | 140 | 58.89 | 3 - 19 |
| 2021-10-23 | UT San Antonio | 60 | 27.94 | 16 - 45 |
| 2021-10-30 | @ Old Dominion | 140 | 54.50 | 20 - 23 |
| 2021-11-06 | @ UAB | 83 | 24.34 | 38 - 52 |
| 2021-11-13 | Charlotte | 152 | 73.48 | 42 - 32 |
| 2021-11-19 | Southern Miss | 177 | 80.89 | 19 - 35 |
| 2021-11-27 | @ Rice | 169 | 53.03 | 31 - 35 |