| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-06 | Mississippi | 24 | 39.93 | 43 - 24 |
| 2021-09-11 | E Kentucky | 171 | 96.48 | 30 - 3 |
| 2021-09-17 | UCF | 33 | 48.44 | 42 - 35 |
| 2021-09-25 | @ Florida St | 104 | 72.17 | 31 - 23 |
| 2021-10-02 | @ Wake Forest | 38 | 38.09 | 34 - 37 |
| 2021-10-09 | Virginia | 58 | 59.02 | 33 - 34 |
| 2021-10-23 | Boston College | 71 | 64.99 | 28 - 14 |
| 2021-10-30 | @ NC State | 24 | 31.88 | 13 - 28 |
| 2021-11-06 | Clemson | 24 | 44.09 | 24 - 30 |
| 2021-11-13 | Syracuse | 59 | 59.20 | 41 - 3 |
| 2021-11-18 | @ Duke | 151 | 90.17 | 62 - 22 |
| 2021-11-27 | Kentucky | 38 | 66.36 | 0 - 0 |