| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | W Michigan | 97 | 85.42 | 47 - 14 |
| 2021-09-11 | Washington | 32 | 61.30 | 31 - 10 |
| 2021-09-18 | N Illinois | 121 | 94.20 | 63 - 10 |
| 2021-09-25 | Rutgers | 59 | 81.95 | 20 - 13 |
| 2021-10-02 | @ Wisconsin | 19 | 51.17 | 38 - 17 |
| 2021-10-09 | @ Nebraska | 19 | 53.96 | 32 - 29 |
| 2021-10-23 | Northwestern | 66 | 85.33 | 33 - 7 |
| 2021-10-30 | @ Michigan St | 15 | 60.28 | 33 - 37 |
| 2021-11-06 | Indiana | 81 | 90.72 | 29 - 7 |
| 2021-11-13 | @ Penn St | 10 | 51.49 | 21 - 17 |
| 2021-11-20 | @ Maryland | 91 | 87.46 | 59 - 18 |
| 2021-11-27 | Ohio St | 1 | 30.43 | 42 - 27 |