| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-02 | MS Valley St | 256 | 95.65 | 35 - 0 |
| 2021-09-11 | @ Cincinnati | 9 | 1.09 | 7 - 42 |
| 2021-09-18 | @ Bowling Green | 197 | 60.80 | 10 - 27 |
| 2021-10-02 | E Illinois | 203 | 69.87 | 22 - 6 |
| 2021-10-09 | @ TN Martin | 145 | 31.25 | 24 - 48 |
| 2021-10-16 | @ SE Missouri St | 174 | 37.90 | 32 - 31 |
| 2021-10-23 | Austin Peay | 192 | 60.65 | 6 - 47 |
| 2021-10-30 | @ Tennessee St | 203 | 37.94 | 21 - 27 |
| 2021-11-06 | Tennessee Tech | 228 | 67.90 | 32 - 27 |
| 2021-11-13 | SE Missouri St | 179 | 37.56 | 28 - 10 |
| 2021-11-20 | @ E Illinois | 234 | 63.65 | 20 - 13 |