| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Marshall | 75 | 41.97 | 7 - 49 |
| 2021-09-11 | Air Force | 56 | 25.22 | 3 - 23 |
| 2021-09-25 | @ Houston | 72 | 19.26 | 20 - 28 |
| 2021-10-02 | UCF | 41 | 20.14 | 34 - 30 |
| 2021-10-09 | SMU | 47 | 27.55 | 24 - 31 |
| 2021-10-14 | @ Memphis | 83 | 31.97 | 17 - 35 |
| 2021-10-23 | Cincinnati | 4 | 5.40 | 20 - 27 |
| 2021-10-29 | @ Tulsa | 104 | 45.53 | 20 - 17 |
| 2021-11-06 | @ Notre Dame | 17 | 12.33 | 6 - 34 |
| 2021-11-20 | East Carolina | 61 | 38.14 | 35 - 38 |
| 2021-11-27 | @ Temple | 193 | 86.66 | 38 - 14 |
| 2021-12-11 | Army | 67 | 37.78 | 0 - 0 |