| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-02 | South Florida | 121 | 83.94 | 45 - 0 |
| 2021-09-11 | @ Mississippi St | 69 | 51.58 | 10 - 24 |
| 2021-09-18 | Furman | 156 | 93.21 | 45 - 7 |
| 2021-09-25 | Clemson | 6 | 19.95 | 27 - 21 |
| 2021-10-02 | Louisiana Tech | 119 | 89.27 | 34 - 27 |
| 2021-10-16 | @ Boston College | 54 | 44.12 | 33 - 7 |
| 2021-10-23 | @ Miami FL | 41 | 47.48 | 30 - 31 |
| 2021-10-30 | Louisville | 44 | 68.12 | 28 - 13 |
| 2021-11-06 | @ Florida St | 59 | 62.78 | 28 - 14 |
| 2021-11-13 | @ Wake Forest | 23 | 50.32 | 42 - 45 |
| 2021-11-20 | Syracuse | 80 | 84.84 | 41 - 17 |
| 2021-11-26 | North Carolina | 61 | 80.71 | 34 - 30 |