| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-03 | @ Virginia Tech | 50 | 65.74 | 10 - 17 |
| 2021-09-11 | Georgia St | 111 | 92.28 | 59 - 17 |
| 2021-09-18 | Virginia | 32 | 72.53 | 59 - 39 |
| 2021-09-25 | @ Georgia Tech | 89 | 83.06 | 22 - 45 |
| 2021-10-02 | Duke | 94 | 85.86 | 38 - 7 |
| 2021-10-09 | Florida St | 101 | 87.67 | 25 - 35 |
| 2021-10-16 | Miami FL | 41 | 59.65 | 45 - 42 |
| 2021-10-30 | @ Notre Dame | 16 | 24.78 | 34 - 44 |
| 2021-11-06 | Wake Forest | 23 | 42.70 | 58 - 55 |
| 2021-11-11 | @ Pittsburgh | 12 | 23.90 | 23 - 30 |
| 2021-11-20 | Wofford | 227 | 98.65 | 34 - 14 |
| 2021-11-26 | @ NC State | 14 | 19.29 | 30 - 34 |