| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Northwestern LA | 196 | 78.15 | 44 - 14 |
| 2021-09-11 | @ SMU | 62 | 9.62 | 12 - 35 |
| 2021-09-18 | UAB | 90 | 26.67 | 6 - 40 |
| 2021-09-25 | @ Louisiana Tech | 113 | 24.18 | 17 - 24 |
| 2021-10-09 | @ Missouri | 86 | 14.25 | 35 - 48 |
| 2021-10-15 | Marshall | 74 | 21.55 | 21 - 49 |
| 2021-10-23 | Liberty | 54 | 12.05 | 26 - 35 |
| 2021-10-30 | @ Rice | 165 | 49.68 | 30 - 24 |
| 2021-11-06 | @ Southern Miss | 183 | 61.42 | 38 - 14 |
| 2021-11-13 | UTEP | 120 | 48.38 | 20 - 17 |
| 2021-11-20 | @ Florida Intl | 199 | 79.07 | 49 - 7 |
| 2021-11-27 | UT San Antonio | 54 | 30.44 | 45 - 23 |