| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | @ Iowa St | 8 | 3.01 | 10 - 16 |
| 2021-09-11 | @ CS Sacramento | 125 | 58.16 | 34 - 16 |
| 2021-09-18 | St Thomas MN | 247 | 98.66 | 44 - 3 |
| 2021-10-02 | Youngstown St | 161 | 85.68 | 34 - 7 |
| 2021-10-09 | @ N Dakota St | 62 | 30.28 | 20 - 34 |
| 2021-10-16 | South Dakota | 120 | 70.65 | 21 - 34 |
| 2021-10-23 | @ S Dakota St | 58 | 21.63 | 26 - 17 |
| 2021-10-30 | S Illinois | 93 | 64.98 | 23 - 16 |
| 2021-11-06 | @ Illinois St | 155 | 80.86 | 10 - 17 |
| 2021-11-13 | @ Missouri St | 79 | 38.83 | 27 - 34 |
| 2021-11-20 | W Illinois | 180 | 88.49 | 41 - 3 |