| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-03 | Michigan St | 68 | 83.19 | 21 - 38 |
| 2021-09-11 | Indiana St | 156 | 96.66 | 24 - 6 |
| 2021-09-18 | @ Duke | 104 | 76.98 | 23 - 30 |
| 2021-09-25 | Ohio | 119 | 87.60 | 35 - 6 |
| 2021-10-02 | @ Nebraska | 31 | 36.85 | 7 - 56 |
| 2021-10-16 | Rutgers | 73 | 59.00 | 21 - 7 |
| 2021-10-23 | @ Michigan | 7 | 14.67 | 7 - 33 |
| 2021-10-30 | Minnesota | 33 | 29.68 | 14 - 41 |
| 2021-11-06 | Iowa | 26 | 21.23 | 12 - 17 |
| 2021-11-13 | @ Wisconsin | 4 | 5.48 | 7 - 35 |
| 2021-11-27 | @ Illinois | 69 | 28.70 | 14 - 47 |