| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-05 | @ Florida St | 96 | 90.33 | 41 - 38 |
| 2021-09-11 | Toledo | 97 | 92.49 | 32 - 29 |
| 2021-09-18 | Purdue | 46 | 76.20 | 27 - 13 |
| 2021-09-25 | Wisconsin | 16 | 47.57 | 41 - 13 |
| 2021-10-02 | Cincinnati | 10 | 56.06 | 13 - 24 |
| 2021-10-09 | @ Virginia Tech | 60 | 70.72 | 32 - 29 |
| 2021-10-23 | USC | 45 | 73.57 | 31 - 16 |
| 2021-10-30 | North Carolina | 48 | 75.22 | 44 - 34 |
| 2021-11-06 | Navy | 93 | 87.67 | 34 - 6 |
| 2021-11-13 | @ Virginia | 28 | 54.01 | 28 - 3 |
| 2021-11-20 | Georgia Tech | 81 | 88.55 | 55 - 0 |
| 2021-11-27 | @ Stanford | 122 | 94.46 | 45 - 14 |