| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Massachusetts | 211 | 98.45 | 51 - 7 |
| 2021-09-11 | @ Tennessee | 58 | 48.87 | 41 - 34 |
| 2021-09-18 | W Michigan | 100 | 81.61 | 41 - 44 |
| 2021-09-25 | New Hampshire | 146 | 92.59 | 77 - 7 |
| 2021-10-02 | @ Georgia Tech | 68 | 57.96 | 52 - 21 |
| 2021-10-16 | @ Virginia Tech | 58 | 63.19 | 28 - 7 |
| 2021-10-23 | Clemson | 11 | 52.27 | 27 - 17 |
| 2021-10-30 | Miami FL | 45 | 82.27 | 34 - 38 |
| 2021-11-06 | @ Duke | 140 | 92.94 | 54 - 29 |
| 2021-11-11 | North Carolina | 46 | 76.10 | 30 - 23 |
| 2021-11-20 | Virginia | 39 | 70.67 | 48 - 38 |
| 2021-11-27 | @ Syracuse | 84 | 77.93 | 31 - 14 |