| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Oregon St | 52 | 49.99 | 30 - 21 |
| 2021-09-11 | @ Connecticut | 192 | 94.32 | 49 - 0 |
| 2021-09-18 | @ Notre Dame | 17 | 23.80 | 13 - 27 |
| 2021-09-25 | Illinois | 94 | 76.47 | 13 - 9 |
| 2021-10-02 | Minnesota | 40 | 49.47 | 13 - 20 |
| 2021-10-16 | @ Iowa | 5 | 9.99 | 24 - 7 |
| 2021-10-23 | Wisconsin | 34 | 52.67 | 13 - 30 |
| 2021-10-30 | @ Nebraska | 20 | 26.40 | 28 - 23 |
| 2021-11-06 | Michigan St | 13 | 40.25 | 40 - 29 |
| 2021-11-13 | @ Ohio St | 2 | 12.90 | 31 - 59 |
| 2021-11-27 | Indiana | 118 | 90.00 | 44 - 7 |