| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-02 | @ SE Missouri St | 156 | 61.79 | 47 - 21 |
| 2021-09-11 | @ Kansas St | 42 | 13.97 | 23 - 31 |
| 2021-09-18 | Dayton | 229 | 96.42 | 55 - 3 |
| 2021-09-25 | Illinois St | 144 | 80.47 | 35 - 17 |
| 2021-10-02 | @ W Illinois | 169 | 78.74 | 31 - 30 |
| 2021-10-09 | @ S Dakota St | 53 | 20.37 | 42 - 41 |
| 2021-10-16 | North Dakota | 121 | 69.38 | 31 - 28 |
| 2021-10-30 | @ Northern Iowa | 77 | 35.02 | 16 - 23 |
| 2021-11-06 | Missouri St | 99 | 61.35 | 28 - 38 |
| 2021-11-13 | @ Indiana St | 183 | 82.76 | 47 - 21 |
| 2021-11-20 | Youngstown St | 174 | 87.21 | 18 - 35 |