| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-02 | S Illinois | 123 | 38.21 | 21 - 47 |
| 2021-09-11 | @ Sam Houston St | 100 | 12.44 | 14 - 52 |
| 2021-09-18 | @ Missouri | 47 | 3.76 | 28 - 59 |
| 2021-09-25 | Tennessee St | 232 | 85.32 | 47 - 14 |
| 2021-10-02 | @ Tennessee Tech | 231 | 80.32 | 17 - 28 |
| 2021-10-09 | @ Austin Peay | 177 | 38.13 | 30 - 14 |
| 2021-10-16 | Murray St | 185 | 62.10 | 31 - 32 |
| 2021-10-23 | @ TN Martin | 135 | 25.58 | 30 - 38 |
| 2021-10-30 | E Illinois | 232 | 81.86 | 38 - 15 |
| 2021-11-13 | @ Murray St | 214 | 62.44 | 10 - 28 |
| 2021-11-20 | TN Martin | 134 | 25.01 | 31 - 14 |