| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | @ Ohio | 81 | 36.41 | 29 - 9 |
| 2021-09-11 | Rutgers | 71 | 49.04 | 7 - 17 |
| 2021-09-18 | SUNY Albany | 174 | 91.33 | 62 - 24 |
| 2021-09-24 | Liberty | 61 | 44.22 | 24 - 21 |
| 2021-10-02 | @ Florida St | 100 | 56.54 | 30 - 33 |
| 2021-10-09 | Wake Forest | 37 | 35.58 | 37 - 40 |
| 2021-10-15 | Clemson | 9 | 17.44 | 14 - 17 |
| 2021-10-23 | @ Virginia Tech | 63 | 38.20 | 41 - 36 |
| 2021-10-30 | Boston College | 84 | 67.15 | 21 - 6 |
| 2021-11-13 | @ Louisville | 52 | 40.80 | 3 - 41 |
| 2021-11-20 | @ NC State | 15 | 15.16 | 17 - 41 |
| 2021-11-27 | Pittsburgh | 15 | 22.07 | 14 - 31 |