| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Norfolk St | 199 | 93.03 | 49 - 10 |
| 2021-09-11 | @ Notre Dame | 11 | 7.51 | 29 - 32 |
| 2021-09-18 | Colorado St | 114 | 74.79 | 6 - 22 |
| 2021-09-25 | @ Ball St | 97 | 45.24 | 22 - 12 |
| 2021-10-02 | @ Massachusetts | 202 | 91.55 | 45 - 7 |
| 2021-10-09 | N Illinois | 129 | 81.63 | 20 - 22 |
| 2021-10-16 | @ C Michigan | 113 | 55.64 | 23 - 26 |
| 2021-10-23 | W Michigan | 78 | 50.25 | 34 - 15 |
| 2021-11-02 | E Michigan | 98 | 67.04 | 49 - 52 |
| 2021-11-10 | @ Bowling Green | 151 | 77.35 | 49 - 17 |
| 2021-11-16 | @ Ohio | 132 | 72.32 | 35 - 23 |
| 2021-11-27 | Akron | 183 | 94.57 | 49 - 14 |