| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-01 | Jacksonville St | 138 | 76.69 | 31 - 0 |
| 2021-09-11 | @ Georgia | 6 | 5.45 | 7 - 56 |
| 2021-09-18 | @ North Texas | 143 | 73.33 | 40 - 6 |
| 2021-09-25 | @ Tulane | 63 | 33.60 | 28 - 21 |
| 2021-10-02 | Liberty | 65 | 52.69 | 12 - 36 |
| 2021-10-09 | FL Atlantic | 69 | 49.10 | 31 - 14 |
| 2021-10-16 | @ Southern Miss | 150 | 78.69 | 34 - 0 |
| 2021-10-23 | Rice | 178 | 93.01 | 24 - 30 |
| 2021-11-06 | Louisiana Tech | 125 | 75.66 | 52 - 38 |
| 2021-11-13 | @ Marshall | 41 | 22.20 | 21 - 14 |
| 2021-11-20 | @ UT San Antonio | 49 | 32.39 | 31 - 34 |
| 2021-11-27 | UTEP | 125 | 80.80 | 42 - 25 |