| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-02 | Boise St | 46 | 62.89 | 36 - 31 |
| 2021-09-11 | Bethune-Cookman | 212 | 98.61 | 63 - 14 |
| 2021-09-17 | @ Louisville | 49 | 51.56 | 35 - 42 |
| 2021-10-02 | @ Navy | 113 | 79.86 | 30 - 34 |
| 2021-10-09 | East Carolina | 85 | 71.87 | 20 - 16 |
| 2021-10-16 | @ Cincinnati | 4 | 11.73 | 21 - 56 |
| 2021-10-22 | Memphis | 77 | 63.06 | 24 - 7 |
| 2021-10-30 | @ Temple | 159 | 82.36 | 49 - 7 |
| 2021-11-06 | Tulane | 120 | 84.74 | 14 - 10 |
| 2021-11-13 | @ SMU | 47 | 37.53 | 28 - 55 |
| 2021-11-20 | Connecticut | 192 | 94.93 | 49 - 17 |
| 2021-11-26 | South Florida | 134 | 82.89 | 17 - 13 |