| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | William & Mary | 167 | 94.77 | 43 - 0 |
| 2021-09-11 | Illinois | 84 | 73.67 | 42 - 14 |
| 2021-09-18 | @ North Carolina | 14 | 27.47 | 39 - 59 |
| 2021-09-24 | Wake Forest | 55 | 64.35 | 17 - 37 |
| 2021-09-30 | @ Miami FL | 33 | 32.93 | 30 - 28 |
| 2021-10-09 | @ Louisville | 49 | 40.98 | 34 - 33 |
| 2021-10-16 | Duke | 105 | 79.98 | 48 - 0 |
| 2021-10-23 | Georgia Tech | 82 | 78.76 | 48 - 40 |
| 2021-10-30 | @ BYU | 52 | 56.76 | 49 - 66 |
| 2021-11-13 | Notre Dame | 15 | 45.99 | 3 - 28 |
| 2021-11-20 | @ Pittsburgh | 17 | 29.33 | 38 - 48 |
| 2021-11-27 | Virginia Tech | 63 | 69.29 | 0 - 0 |