| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-03 | North Carolina | 20 | 34.26 | 17 - 10 |
| 2021-09-11 | MTSU | 114 | 85.80 | 35 - 14 |
| 2021-09-18 | @ West Virginia | 42 | 41.48 | 21 - 27 |
| 2021-09-25 | Richmond | 158 | 94.51 | 21 - 10 |
| 2021-10-09 | Notre Dame | 14 | 29.28 | 29 - 32 |
| 2021-10-16 | Pittsburgh | 18 | 36.81 | 7 - 28 |
| 2021-10-23 | Syracuse | 75 | 61.80 | 36 - 41 |
| 2021-10-30 | @ Georgia Tech | 64 | 40.64 | 26 - 17 |
| 2021-11-05 | @ Boston College | 87 | 58.09 | 3 - 17 |
| 2021-11-13 | Duke | 140 | 84.40 | 48 - 17 |
| 2021-11-20 | @ Miami FL | 42 | 33.67 | 26 - 38 |
| 2021-11-27 | @ Virginia | 42 | 30.71 | 0 - 0 |