| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-03 | Old Dominion | 164 | 95.30 | 42 - 10 |
| 2021-09-11 | Norfolk St | 207 | 98.10 | 41 - 16 |
| 2021-09-18 | Florida St | 101 | 76.12 | 35 - 14 |
| 2021-09-24 | @ Virginia | 35 | 35.65 | 37 - 17 |
| 2021-10-02 | Louisville | 48 | 61.91 | 37 - 34 |
| 2021-10-09 | @ Syracuse | 84 | 64.42 | 40 - 37 |
| 2021-10-23 | @ Army | 72 | 56.61 | 70 - 56 |
| 2021-10-30 | Duke | 127 | 90.71 | 45 - 7 |
| 2021-11-06 | @ North Carolina | 49 | 57.30 | 55 - 58 |
| 2021-11-13 | NC State | 14 | 49.68 | 45 - 42 |
| 2021-11-20 | @ Clemson | 25 | 46.41 | 27 - 48 |
| 2021-11-27 | @ Boston College | 68 | 59.12 | 41 - 10 |