| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-03 | @ Charlotte | 116 | 47.46 | 28 - 31 |
| 2021-09-10 | NC A&T | 144 | 76.20 | 45 - 17 |
| 2021-09-18 | Northwestern | 34 | 23.02 | 30 - 23 |
| 2021-09-25 | Kansas | 149 | 84.12 | 52 - 33 |
| 2021-10-02 | @ North Carolina | 21 | 14.14 | 7 - 38 |
| 2021-10-09 | Georgia Tech | 83 | 48.02 | 27 - 31 |
| 2021-10-16 | @ Virginia | 50 | 20.02 | 0 - 48 |
| 2021-10-30 | @ Wake Forest | 32 | 9.29 | 7 - 45 |
| 2021-11-06 | Pittsburgh | 12 | 7.06 | 29 - 54 |
| 2021-11-13 | @ Virginia Tech | 73 | 15.60 | 17 - 48 |
| 2021-11-18 | Louisville | 27 | 9.83 | 22 - 62 |
| 2021-11-27 | Miami FL | 41 | 9.70 | 10 - 47 |