| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-03 | St Francis PA | 209 | 92.73 | 35 - 15 |
| 2021-09-11 | @ Wisconsin | 13 | 5.31 | 7 - 34 |
| 2021-09-18 | @ Massachusetts | 196 | 84.35 | 42 - 28 |
| 2021-09-25 | Texas St | 136 | 71.26 | 59 - 21 |
| 2021-10-02 | @ N Illinois | 125 | 59.57 | 20 - 27 |
| 2021-10-09 | Miami OH | 98 | 52.16 | 13 - 12 |
| 2021-10-16 | Ball St | 65 | 38.44 | 31 - 38 |
| 2021-10-23 | @ Bowling Green | 185 | 76.46 | 55 - 24 |
| 2021-11-02 | @ Toledo | 74 | 32.96 | 52 - 49 |
| 2021-11-09 | Ohio | 147 | 81.85 | 26 - 34 |
| 2021-11-16 | W Michigan | 122 | 62.40 | 22 - 21 |
| 2021-11-26 | @ C Michigan | 73 | 25.32 | 10 - 31 |