| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-02 | Appalachian St | 51 | 29.52 | 19 - 33 |
| 2021-09-11 | South Carolina | 72 | 43.86 | 17 - 20 |
| 2021-09-18 | @ Marshall | 69 | 28.81 | 42 - 38 |
| 2021-09-25 | Charleston So | 201 | 94.74 | 31 - 28 |
| 2021-10-02 | Tulane | 71 | 36.64 | 52 - 29 |
| 2021-10-09 | @ UCF | 57 | 28.13 | 16 - 20 |
| 2021-10-23 | @ Houston | 35 | 23.14 | 24 - 31 |
| 2021-10-28 | South Florida | 115 | 71.59 | 29 - 14 |
| 2021-11-06 | Temple | 181 | 92.24 | 45 - 3 |
| 2021-11-13 | @ Memphis | 80 | 52.34 | 30 - 29 |
| 2021-11-20 | @ Navy | 97 | 61.86 | 38 - 35 |
| 2021-11-26 | Cincinnati | 9 | 23.58 | 13 - 35 |