| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | NC A&T | 135 | 35.41 | 29 - 18 |
| 2021-09-11 | @ Tennessee Tech | 221 | 73.61 | 26 - 0 |
| 2021-09-18 | @ NC State | 55 | 6.79 | 7 - 45 |
| 2021-09-25 | Mercer | 161 | 56.36 | 3 - 24 |
| 2021-10-09 | @ Wofford | 178 | 40.84 | 42 - 20 |
| 2021-10-16 | Citadel | 203 | 75.24 | 24 - 14 |
| 2021-10-23 | ETSU | 142 | 47.32 | 13 - 17 |
| 2021-10-30 | @ Chattanooga | 107 | 18.09 | 3 - 13 |
| 2021-11-06 | @ W Carolina | 190 | 58.02 | 42 - 43 |
| 2021-11-13 | VMI | 160 | 55.70 | 37 - 31 |
| 2021-11-20 | @ Samford | 169 | 47.27 | 41 - 34 |