| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | N Illinois | 128 | 76.24 | 21 - 22 |
| 2021-09-11 | Kennesaw | 155 | 82.93 | 45 - 17 |
| 2021-09-18 | @ Clemson | 6 | 4.04 | 8 - 14 |
| 2021-09-25 | North Carolina | 15 | 16.94 | 45 - 22 |
| 2021-10-02 | Pittsburgh | 35 | 42.04 | 21 - 52 |
| 2021-10-09 | @ Duke | 102 | 51.98 | 31 - 27 |
| 2021-10-23 | @ Virginia | 26 | 21.24 | 40 - 48 |
| 2021-10-30 | Virginia Tech | 72 | 59.36 | 17 - 26 |
| 2021-11-06 | @ Miami FL | 28 | 20.94 | 30 - 33 |
| 2021-11-13 | Boston College | 76 | 62.09 | 30 - 41 |
| 2021-11-20 | @ Notre Dame | 7 | 11.45 | 0 - 55 |
| 2021-11-27 | Georgia | 2 | 3.30 | 0 - 45 |