| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-08-28 | Nebraska | 37 | 35.96 | 30 - 22 |
| 2021-09-04 | UT San Antonio | 100 | 66.98 | 30 - 37 |
| 2021-09-11 | @ Virginia | 39 | 26.33 | 14 - 42 |
| 2021-09-17 | Maryland | 75 | 46.26 | 17 - 20 |
| 2021-09-25 | @ Purdue | 48 | 23.53 | 9 - 13 |
| 2021-10-02 | Charlotte | 120 | 74.19 | 24 - 14 |
| 2021-10-09 | Wisconsin | 41 | 29.65 | 0 - 24 |
| 2021-10-23 | @ Penn St | 9 | 7.16 | 20 - 18 |
| 2021-10-30 | Rutgers | 85 | 58.32 | 14 - 20 |
| 2021-11-06 | @ Minnesota | 22 | 14.65 | 14 - 6 |
| 2021-11-20 | @ Iowa | 34 | 26.84 | 23 - 33 |
| 2021-11-27 | Northwestern | 99 | 71.30 | 47 - 14 |