| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Butler | 258 | 99.15 | 49 - 7 |
| 2021-09-11 | @ W Michigan | 105 | 25.51 | 0 - 28 |
| 2021-09-18 | @ E Illinois | 214 | 78.85 | 31 - 24 |
| 2021-09-25 | @ S Illinois | 103 | 19.53 | 17 - 35 |
| 2021-10-02 | Missouri St | 131 | 48.55 | 20 - 41 |
| 2021-10-16 | N Dakota St | 61 | 13.68 | 0 - 20 |
| 2021-10-23 | @ South Dakota | 107 | 19.39 | 20 - 14 |
| 2021-10-30 | @ W Illinois | 176 | 57.15 | 31 - 38 |
| 2021-11-06 | Northern Iowa | 73 | 19.14 | 17 - 10 |
| 2021-11-13 | @ North Dakota | 118 | 32.22 | 7 - 14 |
| 2021-11-20 | Indiana St | 193 | 82.01 | 10 - 15 |