| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-03 | South Dakota | 144 | 63.07 | 17 - 14 |
| 2021-09-10 | @ Coastal Car | 47 | 9.14 | 22 - 49 |
| 2021-09-18 | Baylor | 65 | 18.11 | 7 - 45 |
| 2021-09-25 | @ Duke | 96 | 15.88 | 33 - 52 |
| 2021-10-02 | @ Iowa St | 13 | 2.30 | 7 - 59 |
| 2021-10-16 | Texas Tech | 79 | 15.93 | 14 - 41 |
| 2021-10-23 | Oklahoma | 5 | 1.80 | 23 - 35 |
| 2021-10-30 | @ Oklahoma St | 12 | 2.86 | 3 - 55 |
| 2021-11-06 | Kansas St | 37 | 6.31 | 10 - 35 |
| 2021-11-13 | @ Texas | 29 | 3.51 | 57 - 56 |
| 2021-11-20 | @ TCU | 78 | 11.30 | 28 - 31 |
| 2021-11-27 | West Virginia | 50 | 15.35 | 28 - 34 |